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Product Overview
| Product Name | Integrin Alpha V + Beta 6 Antibody |
|---|---|
| Catalog Number | GRP567 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 6 |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
|---|---|
| Concentration | 1ug/ul |
| Storage | Store at -20°C for 12 months. |
| Note | For research use only. |
| Isotype | IgG |
| Clonality | Polyclonal |
| Purity | Purified by Protein A. |
| Entrez | 3685 3694 |
Product Description
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.
Application Notes
| Dilution Range | WB: 1:300-1000, IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP567
IHC-P of GRP567
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