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Product Overview
| Product Name | BAMBI Polyclonal Antibody |
|---|---|
| Catalog Number | GRP616 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Pig |
| Conjugation | Unconjugated |
| Tested applications | FC, IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human BAMBI (public_immunogen_range: 100-150/260) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
BAMBI is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development. The BAMBI family of proteins are related to type I TGF-beta receptor family, however, BAMBI is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain. BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
Application Notes
| Dilution Range | WB: 1:300-1000, FC: 1:20-100, IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP616
IHC-P of GRP616
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