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Product Overview
| Product Name | VE Cadherin Polyclonal Antibody |
|---|---|
| Catalog Number | GRP317 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | FC, ICC, IF, IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from mouse vascular endothelial cadherin (public_immunogen_range: 621-660/784) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Application Notes
| Dilution Range | WB: 1:300-1000, FC: 1:20-100, IHC-P: 1:200-400, IF: 1:50-200 |
|---|
Validation Images
WB of GRP317
IHC-P of GRP317
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