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Product Overview
| Product Name | VDAC3 Polyclonal Antibody |
|---|---|
| Catalog Number | GRP586 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human VDAC3 (public_immunogen_range: 80-120/283) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Application Notes
| Dilution Range | WB: 1:300-1000, IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP586
IHC-P of GRP586
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