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Product Overview
| Product Name | TLR2 Polyclonal Antibody |
|---|---|
| Catalog Number | GRP334 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Bovine |
| Conjugation | Unconjugated |
| Tested applications | FC, ICC, IF, IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human TLR2 (cytoplasmic domain) (public_immunogen_range: 730-780/784) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Application Notes
| Dilution Range | WB: 1:300-1000, FC: 1:20-100, IHC-P: 1:200-400, IF: 1:50-200 |
|---|
Validation Images
WB of GRP334
IHC-P of GRP334
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