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Product Overview
| Product Name | TIMP-1 Polyclonal Antibody |
|---|---|
| Catalog Number | GRP238 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Rabbit |
| Conjugation | Unconjugated |
| Tested applications | ICC, IF, IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human TIMP-1 (public_immunogen_range: 95-145/207) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP1, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Application Notes
| Dilution Range | WB: 1:300-1000, IHC-P: 1:200-400, IF: 1:50-200 |
|---|
Validation Images
WB of GRP238
IHC-P of GRP238
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