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Product Overview
| Product Name | STAT3 (Tyr705) Polyclonal Antibody |
|---|---|
| Catalog Number | GRP422 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Pig |
| Conjugation | Unconjugated |
| Tested applications | FC, IHC-P, WB |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human STAT3 around the phosphorylation site of Tyr705 (public_immunogen_range: 685-725/770) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
Application Notes
| Dilution Range | WB: 1:300-1000, FC: 1:20-100, IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP422
IHC-P of GRP422
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