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Product Overview
| Product Name | Smad7 Polyclonal Antibody |
|---|---|
| Catalog Number | GRP265 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | ELISA, IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human Smad7 (public_immunogen_range: 1-50/426) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
Application Notes
| Dilution Range | WB: 1:300-1000, ELISA: 1:500-1000, IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP265
IHC-P of GRP265
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