PI3 kinase p85 alpha + gamma (Tyr467 + Tyr199) antibody

Catalog Number: GRP511

Product Overview

Product Name	PI3 kinase p85 alpha + gamma (Tyr467 + Tyr199) antibody
Catalog Number	GRP511
Species/Host	Rabbit
Reactivity	Human, Mouse, Rat
Conjugation	Unconjugated
Tested applications	FC, IHC-P, WB
Immunogen	KLH conjugated synthetic phosphopeptide derived from human PI3K around the phosphorylation site of p85 alphaTyr467 (public_immunogen_range: 176-212/461)
Alternative Names	(click to expand) p85; AGM7; GRB1; IMD36; p85-ALPHA; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha; PIK3R1

Product Properties

Form/Appearance	Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Concentration	1ug/ul
Storage	Store at -20°C for 12 months.
Note	For research use only.
Isotype	IgG
Clonality	Polyclonal
Purity	Purified by Protein A.
Uniprot ID	P27986
Entrez	5295

Product Description

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p11 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.

Application Notes

Dilution Range	WB: 1:300-1000, FC: 1:20-100, IHC-P: 1:200-400

Validation Images

WB of GRP511

IHC-P of GRP511

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