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Product Overview
| Product Name | PERK Polyclonal Antibody |
|---|---|
| Catalog Number | GRP478 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | FC, IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human PER (public_immunogen_range: 1080-1116/1116) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity).
Application Notes
| Dilution Range | WB: 1:300-1000, FC: 1:20-100, IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP478
IHC-P of GRP478
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