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p63 antibody [N2C1], Internal

Catalog Number: GRP26

Product Overview
Product Name p63 antibody [N2C1], Internal
Catalog Number GRP26
Species/Host Rabbit
Reactivity Human, Mouse, Rat, Dog
Conjugation Unconjugated
Tested applications ICC, IF, IHC-Fr, IHC-P, IP, WB
Immunogen Recombinant protein encompassing a sequence within the center region of human p63. The exact sequence is proprietary.
Alternative Names
Product Properties
Form/Appearance Liquid: 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Concentration 0.34 mg/ml
Storage Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Note For research use only.
Isotype IgG
Clonality Polyclonal
Purity Purified by antigen-affinity chromatography.
Uniprot ID Q9H3D4
Entrez 8626
Product Description

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq]

Application Notes
Dilution Range WB: 1:500-1:3000,ICC: 1:100-1:1000,IHC-P: 1:100-1:1000,IP: 1:100-1:500
Validation Images
Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with p63 antibody [N2C1], Internal (GRP478) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Immunohistochemical analysis of paraffin-embedded SCC4 xenograft, using p63(GRP478) antibody at 1:100 dilution.
p63 antibody [N2C1], Internal detects TP63 protein by western blot analysis.A. 50 μg rat brain lysate/extract7.5% SDS-PAGEp63 antibody [N2C1], Internal (GRP478) dilution: 1:500 The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary
p63 antibody [N2C1], Internal detects TP63 protein by western blot analysis.A. 50 μg mouse brain lysate/extract7.5% SDS-PAGEp63 antibody [N2C1], Internal (GRP478) dilution: 1:500 The HRP-conjugated anti-rabbit IgG antibody was used to detect the prima
Immunohistochemical characterization of Synaptophysin (GRP478), p63 (GRP478) and Cytokeratin 7 in human small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) specimens.Sample: Paraffin-embedded human SCLC (upper panel) and NSCLC (lower pane
Immunoprecipitation of p63 protein from A431 whole cell extracts using 5 ?g of p63 antibody [N2C1], Internal (GRP478).Western blot analysis was performed using p63 antibody [N2C1], Internal (GRP478).EasyBlot anti-Rabbit IgG was used as a secondary reagen
p63 antibody [N2C1], Internal detects p63 protein at nucleus by immunofluorescent analysis.Sample: A431 cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: p63 stained by p63 antibody [N2C1], Internal (GRP478) diluted at 1:500.Red: alpha Tubul
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