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Product Overview
| Product Name | P21 Polyclonal Antibody |
|---|---|
| Catalog Number | GRP599 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | ICC, IF, IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human P21 (public_immunogen_range: 13-41/164) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Application Notes
| Dilution Range | WB: 1:300-1000, IHC-P: 1:200-400, IF: 1:50-200 |
|---|
Validation Images
WB of GRP599
IHC-P of GRP599
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