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Product Name | MC1 Receptor antibody [C2C3], C-term |
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Catalog Number | GRP123 |
Species/Host | Rabbit |
Reactivity | Human, Mouse |
Conjugation | Unconjugated |
Tested applications | ICC, IF, IHC-P, WB |
Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MC1 Receptor. The exact sequence is proprietary. |
Alternative Names | (click to expand) |
Form/Appearance | Liquid: 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
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Concentration | 0.81 mg/ml |
Storage | Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Note | For research use only. |
Isotype | IgG |
Clonality | Polyclonal |
Purity | Purified by antigen-affinity chromatography. |
Uniprot ID | Q01726 |
Entrez | 4157 |
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq]
Dilution Range | WB: 1:500-1:3000,IHC-P: 1:100-1:1000 |
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