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Product Overview
| Product Name | LC3 Polyclonal Antibody |
|---|---|
| Catalog Number | GRP592 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human LC3 (public_immunogen_range: 27-59/121) |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
|---|---|
| Concentration | 1ug/ul |
| Storage | Store at -20°C for 12 months. |
| Note | For research use only. |
| Isotype | IgG |
| Clonality | Polyclonal |
| Purity | Purified by Protein A. |
| Uniprot ID | Q9H492, Q9GZQ8 |
| Entrez | 84557, 81631 |
Product Description
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Application Notes
| Dilution Range | WB: 1:300-1000, IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP592
IHC-P of GRP592
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