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Product Overview
| Product Name | IL1 Receptor antagonist antibody |
|---|---|
| Catalog Number | GRP119 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | ICC, IF, IHC-P, WB |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human IL1 Receptor antagonist. The exact sequence is proprietary. |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | Liquid: 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
|---|---|
| Concentration | 1 mg/ml |
| Storage | Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Note | For research use only. |
| Isotype | IgG |
| Clonality | Polyclonal |
| Purity | Purified by antigen-affinity chromatography. |
| Uniprot ID | P18510 |
| Entrez | 3557 |
Product Description
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
Application Notes
| Dilution Range | WB: 1:500-1:3000,ICC: 1:100-1:1000,IHC-P: 1:100-1:1000 |
|---|
Validation Images
IL1 Receptor antagonist antibody detects IL1RN protein by western blot analysis.A. 30 μg Neuro2A whole lysate/extract B. 30 μg C8D30 whole cell lysate/extract C. 30 μg NIH-3T3 whole cell lysate/extract D. 30 μg Raw264.7 whole cell lysate/extra
Immunofluorescence analysis of methanol-fixed HeLa, using IL1ra antagonist (GRP571) antibody at 1:200 dilution.
Immunohistochemical analysis of paraffin-embedded PC3 xenograft, using IL1 Receptor antagonist(GRP571) antibody at 1:500 dilution.
IL1 Receptor antagonist antibody detects IL1RN protein by western blot analysis.A. 30 μg PC-12 whole cell lysate/extract15% SDS-PAGEIL1 Receptor antagonist antibody (GRP571) dilution: 1:1000 The HRP-conjugated anti-rabbit IgG antibody was used to dete
IL1 Receptor antagonist antibody detects IL1 Receptor antagonist protein by Western blot analysis. Various whole cell extracts (30 ?g) were separated by 15 % SDS-PAGE, and blotted with IL1 Receptor antagonist antibody (GRP571) diluted by 1:1000
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