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Product Overview
| Product Name | Histone H2A.X (Ser140) Antibody |
|---|---|
| Catalog Number | GRP507 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | IHC-P |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human Histone H2AX around the phosphorylation site of Ser140 (public_immunogen_range: 100-142/143) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Application Notes
| Dilution Range | IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP507
IHC-P of GRP507
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