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Product Overview
| Product Name | F8 - Coagulation factor VIII |
|---|---|
| Catalog Number | GRP13213 |
| Species/Host | Chicken |
| Reactivity | Human |
| Predicted Reactivity | Human |
| Immunogen | purified full length native human Coagulation Factor VIII-VWF-F VIII:c complex |
Product Properties
| Form/Appearance | Liquid in 0.9% NaCl, 0.1% sodium azide |
|---|---|
| Storage | Store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes. |
| Note | For research use only. |
| Clonality | Polyclonal |
| Purity | Total IgY fraction |
| MW | 267 kDa |
Application Notes
| Dilution Range | 1 : 200 (IHC) |
|---|---|
| Application Notes | Additional Information: Immunohistochemistry: antibody was tested on bonin-fixed rat blood vessel. IgG concentration is 22.2 µg/µl Background: The factor VIII complex, with a molecular weight in excess of 1 million, has 2 components: (1) factor VIII P00451 (molecular weight of 267 kDa) called factor VIII C, when measured by procoagulant activity or factor VIII Ag, when measured immunologically; (2) factor VIII R P04275 (the von Willebrand factor or vWF) has a molecular weight of 225 kDa. Factor VIII, along with calcium and phospholipids, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Domain F5/8 type C 2 Is responsible for phospholipid binding and essential for factor VIII activity. Defects in F8 are the cause of hemophilia A (HEMA). HEMA is a common recessive X-linked coagulation disorder. |
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