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Estrogen receptor beta Antibody

Catalog Number: GRP198

Product Overview
Product Name Estrogen receptor beta Antibody
Catalog Number GRP198
Species/Host Rabbit
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Tested applications FC, IHC-P, WB
Immunogen KLH conjugated synthetic peptide derived from human ER-beta (public_immunogen_range: 220-270/530)
Alternative Names
Product Properties
Form/Appearance Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Concentration 1ug/ul
Storage Store at -20°C for 12 months.
Note For research use only.
Isotype IgG
Clonality Polyclonal
Purity Purified by Protein A.
Uniprot ID Q92731
Entrez 2100
Product Description

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Application Notes
Dilution Range WB: 1:300-1000, FC: 1:20-100, IHC-P: 1:200-400
Validation Images
WB of GRP198
IHC-P of GRP198
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