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Product Overview
Product Name | E2F1 Polyclonal Antibody |
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Catalog Number | GRP272 |
Species/Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Conjugation | Unconjugated |
Tested applications | IHC-P, WB |
Immunogen | KLH conjugated synthetic peptide derived from human E2F1 (public_immunogen_range: 105-135/437) |
Alternative Names | (click to expand) |
Product Properties
Product Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis.
Application Notes
Dilution Range | WB: 1:300-1000, IHC-P: 1:200-400 |
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