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Product Overview
| Product Name | DKK1 Polyclonal Antibody |
|---|---|
| Catalog Number | GRP459 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Dog |
| Conjugation | Unconjugated |
| Tested applications | IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human DKK1 (public_immunogen_range: 207-247/266) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Application Notes
| Dilution Range | WB: 1:300-1000, IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP459
IHC-P of GRP459
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