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Product Overview
Product Name | CD80 Polyclonal Antibody |
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Catalog Number | GRP464 |
Species/Host | Rabbit |
Reactivity | Mouse, Rat |
Conjugation | Unconjugated |
Tested applications | IHC-P, WB |
Immunogen | KLH conjugated synthetic peptide derived from rat CD80 (public_immunogen_range: 270-321/321) |
Alternative Names | (click to expand) |
Product Properties
Product Description
CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines.
Application Notes
Dilution Range | WB: 1:300-1000, IHC-P: 1:200-400 |
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