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CD163/M130 Polyclonal Antibody

Catalog Number: GRP480

Product Overview
Product Name CD163/M130 Polyclonal Antibody
Catalog Number GRP480
Species/Host Rabbit
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Tested applications FC, ICC, IF, IHC-P, WB
Immunogen KLH conjugated synthetic peptide derived from human CD163/M130 (public_immunogen_range: 800-850/1156)
Alternative Names
Product Properties
Form/Appearance Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Concentration 1ug/ul
Storage Store at -20°C for 12 months.
Note For research use only.
Isotype IgG
Clonality Polyclonal
Purity Purified by Protein A.
Uniprot ID Q86VB7
Entrez 9332
Product Description

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Application Notes
Dilution Range WB: 1:300-1000, FC: 1:20-100, IHC-P: 1:200-400, IF: 1:50-200
Validation Images
WB of GRP480
IHC-P of GRP480
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