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CXCR4 Polyclonal Antibody

Catalog Number: GRP331

Product Overview
Product Name CXCR4 Polyclonal Antibody
Catalog Number GRP331
Species/Host Rabbit
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Tested applications FC, IHC-P, WB
Immunogen KLH conjugated synthetic peptide derived from human CXCR4 (public_immunogen_range: 217-241/352)
Alternative Names
Product Properties
Form/Appearance Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Concentration 1ug/ul
Storage Store at -20°C for 12 months.
Note For research use only.
Isotype IgG
Clonality Polyclonal
Purity Purified by Protein A.
Entrez 7852
Product Description

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Application Notes
Dilution Range WB: 1:300-1000, FC: 1:20-100, IHC-P: 1:200-400
Validation Images
WB of GRP331
IHC-P of GRP331
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