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Product Overview
| Product Name | Caspase 3 Polyclonal Antibody |
|---|---|
| Catalog Number | GRP193 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Bovine, Goat |
| Conjugation | Unconjugated |
| Tested applications | ICC, IF, IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from human Caspase 3(Active) (public_immunogen_range: 60-100/277) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Application Notes
| Dilution Range | WB: 1:300-1000, IHC-P: 1:200-400, IF: 1:50-200 |
|---|
Validation Images
WB of GRP193
IHC-P of GRP193
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