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Active Caspase 3 Monoclonal Antibody

Catalog Number: GRP629

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Datasheet
Product Overview
Product Name Active Caspase 3 Monoclonal Antibody
Catalog Number GRP629
Species/Host Mouse
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Tested applications IHC-P, WB
Immunogen Recombinant human Active Caspase 3
Alternative Names (click to expand) Caspase-3 subunit p17; APOPAIN; CASP3; Caspase 3 apoptosis related cysteine protease; Caspase3; CPP32; CPP32B; Cysteine protease CPP32; Human cysteine protease CPP32 isoform alpha mRNA complete cds; PARP cleavage protease; SCA 1; SCA1; SREBP cleavage activity 1; Yama; CASP3_HUMAN; Caspase-3; CASP-3; Apopain; Protein Yama; SREBP cleavage activity 1; SCA-1.
Product Properties
Form/Appearance 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration 1ug/ul
Note For research use only.
Isotype IgG
Clonality Monoclonal
Purity Purified by Protein A.
Clone ID 70
Uniprot ID P42574
Entrez 836
Product Description

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Application Notes
Dilution Range WB: 1:300, IHC-P: 1:400
Validation Images
WB of GRP629
WB of GRP629
IHC-P of GRP629
IHC-P of GRP629
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