Availability

Fibrinogen, Biotin conjugated

Catalog Number: GRP13238

Product Overview
Product Name Fibrinogen, Biotin conjugated
Catalog Number GRP13238
Species/Host Chicken
Reactivity Human
Predicted Reactivity Bovine, Mouse, Porcine, Rabbit, Rat
Tested applications WB, ID
Immunogen Purified, full length native fibrinogen UniProt: Q9UE34
Product Properties
Form/Appearance Liquid in 0.15M sodium chloride, 0.02M sodium phosphate, 0.1% sodium azide, pH 7.2
Storage Store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Note For research use only.
Clonality Polyclonal
Purity Affinity purified IgY
MW 75 kDa
Uniprot ID Q9UE34
Application Notes
Dilution Range 1 : 5000 (WB)
Application Notes Additional Information: Only one precipitation arc in immunodiffusion and immunoelectrophoresis against normal human plasma or human fibrinogen. Background: Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989).
Reviews
Write Your Own Review
You're reviewing:Fibrinogen, Biotin conjugated - GRP13238
Your Rating