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Product Overview
Product Name | Active Caspase 3 Monoclonal Antibody |
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Catalog Number | GRP629 |
Species/Host | Mouse |
Reactivity | Human, Mouse, Rat |
Conjugation | Unconjugated |
Tested applications | IHC-P, WB |
Immunogen | Recombinant human Active Caspase 3 |
Alternative Names | (click to expand) |
Product Properties
Product Description
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Application Notes
Dilution Range | WB: 1:300, IHC-P: 1:400 |
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