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Product Overview
| Product Name | Caspase 3 Polyclonal Antibody |
|---|---|
| Catalog Number | GRP484 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | FC, IHC-P, WB |
| Immunogen | KLH conjugated synthetic peptide derived from rat Caspase 3 (public_immunogen_range: 1-45/277) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).
Application Notes
| Dilution Range | WB: 1:300-1000, FC: 1:20-100, IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP484
IHC-P of GRP484
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