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Product Overview
| Product Name | Anti-Hu CD268 FITC |
|---|---|
| Catalog Number | GRP13271 |
| Reactivity | Human |
| Tested applications | FC |
| Immunogen | human CD268-transfected murine L1.2 cells |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | FITC |
|---|---|
| Preservatives | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Storage | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
| Note | For research use only. |
| Isotype | Mouse IgG1 kappa |
| Clone ID | 11C1 |
| Uniprot ID | Q96RJ3 |
| NCBI | 115650 |
Product Description
CD268 / BAFF R is a TNFR family receptor that binds the B-cell-activating factor (CD257 / BAFF). Splice variants of CD268 have been observed both in man and mouse. A naturally occurring mutation of CD268 in A/WySnJ mice is associated with low number of mature B cells, but with normal B cell precursors. The role of BAFF in B-cell survival and activation make CD268 a potential diagnostic reagent. It may be involved in survival of B-cell malignancies. Experimental administration of a CD268-Fc fusion protein suppresses antibody responses. In T cells the CD268 costimulates their activation and proliferation. Defects in CD268 cause the common variable immunodeficiency 4 (CVID4).
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