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Product Overview
| Product Name | Anti-Hu CD205 APC |
|---|---|
| Catalog Number | GRP13272 |
| Reactivity | Human |
| Tested applications | FC |
| Immunogen | Recombinant Fc-tagged human CD205 |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | APC |
|---|---|
| Preservatives | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Storage | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
| Note | For research use only. |
| Isotype | Mouse IgG1 kappa |
| Clone ID | HD30 |
| Uniprot ID | O60449 |
| NCBI | 4065 |
Product Description
CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells.
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