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Anti-Granzyme B FITC

Catalog Number: GRP13258

Product Overview
Product Name Anti-Granzyme B FITC
Catalog Number GRP13258
Reactivity Human, Primate
Tested applications FC
Immunogen Human NK cell line YT-INDY-derived granzyme B
Alternative Names
Product Properties
Form/Appearance FITC
Preservatives Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Note For research use only.
Isotype Mouse IgG1
Clone ID CLB-GB11
Uniprot ID P10144
NCBI 3002
Product Description

Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.

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