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Product Overview
| Product Name | Anti-Granzyme B FITC |
|---|---|
| Catalog Number | GRP13258 |
| Reactivity | Human, Primate |
| Tested applications | FC |
| Immunogen | Human NK cell line YT-INDY-derived granzyme B |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | FITC |
|---|---|
| Preservatives | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Storage | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
| Note | For research use only. |
| Isotype | Mouse IgG1 |
| Clone ID | CLB-GB11 |
| Uniprot ID | P10144 |
| NCBI | 3002 |
Product Description
Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.
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