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Product Overview
| Product Name | Anti-DLL4 PE |
|---|---|
| Catalog Number | GRP13259 |
| Reactivity | Human |
| Tested applications | FC |
| Immunogen | recombinant soluble human DLL4 |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | PE |
|---|---|
| Concentration | 0.1 mg/ml |
| Preservatives | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Storage | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
| Note | For research use only. |
| Isotype | Mouse IgG1 kappa |
| Clone ID | MHD4-46 |
| Uniprot ID | Q9NR61 |
| NCBI | 54567 |
Product Description
DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.
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