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AKT1/2/3 (Ser472/Ser473/Ser474) Antibody
Catalog Number: GRP316
Product Overview
| Product Name | AKT1/2/3 (Ser472/Ser473/Ser474) Antibody |
|---|---|
| Catalog Number | GRP316 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | IHC-P, WB |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human AKT1 around the phosphorylation site of Ser473 (public_immunogen_range: 450-480/480) |
| Alternative Names | (click to expand) |
Product Properties
Product Description
AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
Application Notes
| Dilution Range | WB: 1:300-1000, IHC-P: 1:200-400 |
|---|
Validation Images
WB of GRP316
IHC-P of GRP316
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