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Product Overview
| Product Name | ADAM17 antibody [C2C3], C-term |
|---|---|
| Catalog Number | GRP103 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Tested applications | IHC-P, WB |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human ADAM17. The exact sequence is proprietary. |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | Liquid: 1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
|---|---|
| Concentration | 1 mg/ml |
| Storage | Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Note | For research use only. |
| Isotype | IgG |
| Clonality | Polyclonal |
| Purity | Purified by antigen-affinity chromatography. |
| Uniprot ID | P78536 |
| Entrez | 6868 |
Product Description
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq]
Application Notes
| Dilution Range | WB: 1:500-1:3000,IHC-P: 1:100-1:1000 |
|---|
Validation Images
![Whole cell extract (30 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with ADAM17 antibody [C2C3], C-term (GRP555) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.](https://www.grp-ak.de/media/catalog/product/a/d/adam17-antibody-c2c3-c-term_grp555_wb_3_2.jpg)
![ADAM17 antibody [C2C3], C-term detects ADAM17 protein by western blot analysis.A. 30 μg K562 whole cell lysate/extract](https://www.grp-ak.de/media/catalog/product/a/d/adam17-antibody-c2c3-c-term_grp555_wb_2_2.jpg)
![7.5% SDS-PAGEADAM17 antibody [C2C3], C-term (GRP555) dilution: 1:500 The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.](https://www.grp-ak.de/media/catalog/product/a/d/adam17-antibody-c2c3-c-term_grp555_ihc_1_2.jpg)
![ADAM17 antibody [C2C3], C-term detects ADAM17 protein at cytosol on human breast carcinoma by immunohistochemical analysis. Sample: ADAM17 antibody [C2C3], C-term (GRP555) dilution: 1:250.](https://www.grp-ak.de/media/catalog/product/a/d/adam17-antibody-c2c3-c-term_grp555_wb_1_2.jpg)
Whole cell extract (30 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with ADAM17 antibody [C2C3], C-term (GRP555) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
ADAM17 antibody [C2C3], C-term detects ADAM17 protein by western blot analysis.A. 30 μg K562 whole cell lysate/extract
7.5% SDS-PAGEADAM17 antibody [C2C3], C-term (GRP555) dilution: 1:500 The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
ADAM17 antibody [C2C3], C-term detects ADAM17 protein at cytosol on human breast carcinoma by immunohistochemical analysis. Sample: ADAM17 antibody [C2C3], C-term (GRP555) dilution: 1:250.
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